Tranquilene Review – Is It Worth It? [2022 Update]

Tranquilene Review


  • Short-term brain stimulation
  • Reduction in stress and anxiety


  • Stomach ache
  • Headache
  • Tiredness
  • Nausea
  • Morning sickness
  • Interference with blood thinners, antidepressants, and sedatives


By supporting the production of GABA and serotonin in the body, Tranquilene claims to provide relief from stress and anxiety. It combines traditional herbs alongside western medicine to correct emotional imbalances. Tranquilene also contains a couple of nootropic herbs like Ashwagandha and Bacopa, that promote cognitive improvement. However, the formula is far from perfect due to the side-effects of L-tryptophan. The presence of caffeine does not do any good to the product either. All in all, it comes across as a mediocre nootropic supplement. We advise that you spend your hard-earned money on a supplement that comes from a trusted brand and contains high-quality and well-researched ingredients.

Tranquilene, as the name suggests, helps to reduce anxiety and achieve calmness. 

People suffering from anxiety or constant stress feel the burden of day-to-day tasks. Life, in general, can become exhausting for them. In our quest to find a purposeful supplement that serves the brain’s function and emotional health, we came across Tranquilene.  

Our research team went behind the professed claims to find out its actual efficacy and safety.

Read on to see what we have discovered…

What is Tranquilene?

Tranquilene is an all-natural supplement that mitigates anxiety and helps to correct stress-causing nutritional imbalances over time. 

Its formula is composed of proven western ingredients and traditional eastern herbs. Tranquilene works by managing the serotonin and GABA levels in the body to provide calmness.

About Manufacturer

It is manufactured by Tranquility Labs, a producer of brain health supplements based in Massachusetts. Rob Barry is the founder, and his father was a naturopath.

They specialize in all-natural dietary supplements. The tranquillity labs supplements are manufactured in FDA and GMP registered pharmaceutical facility in the USA. 

The company takes pride in bringing together the traditional eastern herbal medicine with western nutritional science to provide the best quality supplements.

Tranquilene Claims

Tranquilene claims to be a comprehensive anti-anxiety supplement that provides not just immediate relief, but long-term benefits in correcting nutritional imbalances. Some of the claims made include:

  • Providing comfort from stress and anxiety
  • Boosting mood and relaxation naturally
  • Boosting brain performance and restoring emotional balance
  • Supporting production of GABA and serotonin

Tranquilene Ingredients Analysis

The principal premise of Tranquility is the blend of western science with eastern herbs. We were curious to look into the ingredient list, that sounds very promising as follows:

  • Passion Flower
  • GABA
  • L-Tryptophan
  • Ashwagandha
  • Brahmi (Bacopa Monnieri)
  • L-Theanine
  • Green tea extract 
  • Calcium Carbonate
  • Vitamin D3
  • B Vitamins
  • Magnesium Citrate

Passion Flower

Passionflower is a climbing vine plant that is native to America. It has been used to treat sleep and anxiety issues.

The oral consumption of this plant is known to increase the level of GABA, which in turn helps to reduce stress. In a study published in Phytotherapy Research participants that were given passionflower tea for seven days showed improvements in anxiety and sleep irregularities.

Key point: According to a study by the National Centre for Complementary and Integrative Health, consumption of passiflora supplements can lead to dizziness and confusion. Since Passiflora works by reducing brain-activity and inducing sleep, it can be potentially dangerous to consume before driving.


Gamma-aminobutyric acid or GABA is an amino acid that occurs naturally in the body. It works by acting as an inhibitory neurotransmitter that blocks stress-related signals and relaxes the nervous system.  

Conclusive scientific studies on GABA have not been conducted yet. A study published by Frontiers in Psychology presses upon the need for more scientific research to assess the working of GABA and its long-term effects.

Key point: Commonly reported side-effects of GABA supplements include upset stomach, headache, sleepiness, and muscle weakness. 


Tryptophan is an essential amino acid and is known to help in the creation of serotonin. Foods that are high in protein like chicken, eggs, fish, etc. are a good source of natural Tryptophan. 

Proponents agree it can promote better sleep, relief from depression, and anxiety. 

Consuming it in a supplement form may have certain side-effects like heartburn, stomach pain, vomiting, and diarrhea. A report published by the National Organization for Rare Disorders examines a rare disease caused by the consumption of Tryptophan supplement, called eosinophilia-myalgia syndrome (EMS). This disease caused 37 deaths in an epidemic in the 1980s. 

Further, it may increase the serotonin to a level more than required, especially if taken along with other serotonin increasing medications. It may also worsen the liver and kidney diseases because of its ties to EMS.

As per scientific studies, this ingredient is potentially unsafe to consume.


Ashwagandha is an important ancient herb used in Ayurveda for the treatment of various ailments. It has plenty of benefits, but the ones related to brain health include relieving stress, increasing energy levels, and improving concentration. (1) (2

Though there are no long-term studies conducted on this herb, it is generally considered safe to consume for healthy people. Pregnant and nursing women and people with autoimmune disease should avoid it.

Brahmi (Bacopa Monnieri)

Bacopa is an ayurvedic herb used since ages to enhance memory, relieve stress, and increase focus. Studies support its positive impact on retaining and learning in humans. (1)


Theanine, extracted from the tea leaves, is an amino acid that helps to reduce anxiety and stress.  

Studies confirm its positive effect on mental alertness (1). A report published by MDPI supports the anti-stress effects of Theanine. Further, it helps in relaxation without causing drowsiness (1).

Green Tea Extract 

Green tea extract serves the purpose of caffeine, which provides immediate stimulation to the brain. Also, it helps in improving mood and mental alertness. 

Studies report no potential side-effect of caffeine if consumed in small amounts. If you already consume caffeine in your daily diet, there can be a case of over-stimulation.

Calcium Carbonate

The deficiency of calcium leads to weaker bones, which can increase muscle tension and stress. 

Although essential for normal body functions, we suggest you consult a physician and take tests for deficiencies when deciding for a supplement that contains calcium and Vit D as too much calcium in the body can cause nausea, vomiting, constipation, confusion, and lack of energy. 

There’s a possibility of medicine interference as calcium can make the absorption of other medicines harder for the body.

Vitamin D3

Vitamin D is essential for maintaining optimum bone health as it helps the body to absorb calcium. It also plays a role in preventing heart conditions and balancing blood pressure.

An oral consumption of Vit D does not possess any harmful risks if taken in the recommended dose. If consumed for a longer time in high doses, there’s a potential risk of developing high calcium content in the blood.

B Vitamins

The B-vitamins are essential micro-nutrients that perform critical functions in the body to maintain proper health and brain performance. They help the body to process the nutrients and convert food into energy. Each B vitamin plays a unique role in the body. 

Studies confirm that consuming a small dose of B-complex contains no side-effects for the body.

Magnesium Citrate

Magnesium is another essential mineral found in the body. It is used as a supplement mainly to treat constipation as it acts as a laxative. 

Before starting a magnesium supplement, check with a doctor if you have any kidney disease, stomach pain, or nausea.

Are Tranquilene Ingredients Safe & Effective?

When it comes to supplements, the safety of use is of prime importance.

Tranquility Labs does contain some powerful nootropics that help in better brain functioning. Bacopa, Ashwagandha and L-Theanine are active ingredients for brain health and emotional distress and have undergone many clinical trials.

Bacopa and Ashwagandha are potent herbs that have been used for ages to improve memory, and boost focus.

Our only concern here is with Tryptophan. It is one of the critical ingredients in Tranquilene because of its effectiveness.

However, there are serious concerns regarding its safety. We recommend you to take into consideration its potential side-effects if you are assessing it for use, including:

  • Drowsiness
  • Fatigue
  • Stomach upset
  • Headache
  • Morning grogginess
  • Increased effects of sedative drugs
  • Lowering of blood pressure

We did not find much evidence for including Calcium, Vit D, and magnesium in a nootropic formula except that it supports overall bone, and muscle health, which may be indirectly linked to reducing stress.

Warnings for Tranquilene Users

The official website suggests consulting a physician before taking Tranquilene for pregnant and nursing women.

Drug interaction can take place if you are taking blood thinners, muscle relaxants, or any other pain-relieving or sedative medicines.

How to Take Tranquilene?

The official website states to consume two pills a day with water, either both in the morning or one in the morning and the other in the afternoon.

Does Tranquilene Provide 100% BrainPower?

Tranquilene serves its purpose by reducing stress and increasing serotonin and GABA, which may eventually lead to a healthier brain and a calm mind. Bacopa and Ashwagandha are two nootropics that have been used for ages to improve memory, focus, and learning. 

Although a great formula, the supplement would have been more potent and effective with the addition of a few other vital ingredients. Lion’s mane mushroom is one such ingredient, which has proven to show invariable positive results in supporting overall brain health by stimulating the New Growth Factor Product (NGFP). 

Also, it is missing on L-Tyrosine, which is a powerful element and works with neurotransmitters to help with memory, mood, and mental processing. 

Overall, it’s a great formula, but with the addition of a few other ingredients, it would have been a much more compelling stack.

Customers Reviews

Here are some of the customer reviews that we found:

Hello everyone I want to share my experience with Tranquiline, I had the worst anxiety (panic attacks)and first time with depression crisis in my life since the beginning of this year, it was a nightmare! I have one month taking two pills daily and I began feeling better in the third week. Anxiety and depression have not completely gone, but at least I feel better. I'm gonna order my second bottle and I will keep posting how is working.

Dahlia M

Had terrible side effects from this “natural” supplement!!! Starting from day one, upset stomach and bad headache that got progressively worse each day the supplement was taken. Headache became migraine strength by day four, accompanied by jaw and neck pain. PLUS I found I was clenching my jaw/grinding my teeth! I was lightheaded and feeling edgy at the same time. Could not relax. By day six, couldn't stand it anymore and discontinued use. Headache was fading by evening and completely gone the next day. Will NOT be taking this ever again.


These pills really did nothing for me. In fact I think they generally made me feel worse then when I didn’t take them. I went about 5 or 6 days without taking them, after taking them for almost 3 weeks straight, and felt much better. In those five or six days I took vitamin B supplements and D supplements, I think I’ll add in some magnesium supplements and call it good. I was really hoping these would work well but didn’t at all.

Chad Lerum

Where to Buy Tranquilene?

Tranquilene can be bought from their official website and Amazon. 

  • One bottle of Tranquilene (60 capsules) costs $ 42.5 

Return Policy & Money-Back Guarantee

The company offers a full money refund only on the unopened bottles if sent within 60 days of purchase.

Is Tranquilene A Good Nootropic For You?

Tranquilene is a powerful supplement that has shown impressive results in combating stress and anxiety. The ingredients work together to calm the mind and boost brain productivity. 

However, as previously stated, we suggest you research thoroughly about Tryptophan before deciding to include it in the daily supplements. 

If you’re looking for a safer option that comes with a scientifically-backed ingredients list, then we suggest you consider one of the best nootropics available, Mind Lab Pro

Mind Lab Pro contains some power-packed ingredients like Lion’s mane mushroom, Rhodiola Rosea, and L Tyrosine that are acclaimed for their stress-busting and cognition-enhancing capacity. Do read our complete review of this product here.

Comparison Table

Enter your text here...

Tranquilene Review


Mind Lab Pro Review

Mind Lab Pro

Support Memory?

Encoding, Storage, Recall, Learning, Test Taking

Support Brain Energy?

Mental agility, quick thinking and focus

Supports Mindset

Mood balance, Stress resistance, Relaxation, Creativity, Motivation

Supports Focus

Supports Brain Protection

Fights toxins and unhealthy structural changes that degrade the brain over time.

Supports Performance

Speed, Process, Attention, Focus, Verbal

Supports Structural

Injury repair, Fluid membranes, Neurogenesis, Anti-aging, Fight depression

Meets mental performance demand

From day to day and hour to hour

Helps with immediate and long-term brain health and function

Free from stimulants and additives

Side Effects

Stomach ache, Headache, Tiredness, Nausea, Interference with other medicines

No Potential Side Effects


Per Bottle



Free Shipping




Money Back Guarantee

60 Days (Only if bottle is unopened)

30 Days


Based on our research, Tranquilene justifies some of the claims it has made. We admire the use of herbs like Bacopa and Ashwagandha, but it would have been a more potent formula with the addition of a few more essential nootropic agents. 

That aside, there are mixed reviews regarding the safety of Tryptophan. For us, that acts as a deal-breaker.

If you are in search of a nootropic that performs its function without any side effects, then we recommend Mind Lab Pro. It is touted as the cleanest brain supplement that has no additives and is 100% vegan - interested to learn more about it? 

Last Updated On: June 23rd, 2022

Your Thoughts?

Leave a reply

Finding Optimism