EMPowerplus Advanced Review – 12 Facts You Need to Know

EMPowerplus Advanced Review – 12 Facts You Need to Know
EMPowerplus Advanced Review – 12 Facts You Need to Know

EMPowerplus Advanced is a micronutrient formula that has been in the market for a very long time. It is one of the most popular micronutrient supplements in Canada. 

Last Updated On: June 23rd, 2022


EMPowerplus Advanced is a brain supplement that contains a bunch of vitamins with some added ingredients. 

The company claims that EMPowerplus Advanced can help improve mental health and prove fruitful for overall mental wellbeing.

Truehope's official website mentions the manufacturer's personal story where his family suffered from severe mental disorders. 

There are claims that the formula used in EMPowerplus is the original formula that helped his family recover from bipolar disorder.

However, we had specific questions in mind.

Is this formula that effective?

Are the ingredients backed by scientific literature to benefit against neurological disorders? 

For that purpose, we acquainted ourselves with all the ingredients and consulted the scientific literature so that we could know the truth.

Here's what we found…

What is EMPowerplus?

EMPowerplus Advanced is a micronutrient formula developed originally as a multivitamin supplement. 

The manufacturer also promotes it as a nootropic that can cure mental illness, including stress, depression, and severe mental ailments like ADHD and bipolar.

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About Manufacturer

EMPowerplus Advanced is manufactured by Truehope. It is based in Raymond, Canada. 

Other products in the Truehope catalog are:

  • Aminopower Advanced
  • Inositol
  • Phosphatidylcholine
  • Greenbac
  • Olive Leaf Extract
  • BMD Advanced
  • Nascent Iodine Advanced

Truehope was founded in 1996 by Anthony Stephan and David Hardy.

Stephan's family suffered from neurological deficit, and according to him, EMPowerplus Advanced is the formula that helped his family recover.

Truehope was sued by Health Canada for a possible risk of the supplement to patients' health. The Truehope lawsuit, however, ended in a win for the manufacturers. 

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 EMPowerplus Claims

Truehope claims that EMPowerplus Advanced:

  • Helps fight stress
  • Supports energy
  • Improves Focus
  • Alleviates Anxiety
  • Assists in depression
  • Cures bipolar disorder
  • Helps get rid of mood swings
  • Treats ADHD
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EMPowerplus Ingredients Analysis

The micronutrient formula contains:

  • Vitamin A
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin B-complex
  • Choline Bitartrate
  • Phenylalanine
  • Inositol
  • Ginkgo biloba 
  • Grape seed extract 
  • L- glutamine
  • Trace elements (like iron, calcium, phosphorus)

Vitamin A

Vitamin A is an essential fat-soluble vitamin. It plays a role in the synthesis of visual pigments in the eyes. 

Research in Karger found that vitamin A intake can help in better development of the hippocampus and hypothalamus.

A healthy hippocampus is essential for storing long-term memories, while the hypothalamus regulates many vital physiological functions in the body.

Vitamin C

Vitamin C is a water-soluble vitamin. It is present in large amounts in citrus fruits like oranges and lemons.

Multidisciplinary Digital Publishing Institute states in a review article that vitamin C in the form of ascorbic acid can play a role in combating aging and Alzheimer's disease.

A study has also shown that vitamin C can act as a neuroprotective agent. It does so through its antioxidant role. 

Vitamin D

Vitamin D is a fat-soluble vitamin necessary for the deposition of calcium in bones and teeth.

Elsevier says that vitamin D is essential for neurotransmission and immunomodulation. However, the mechanism is still unclear.

Research on Karger says that vitamin D deficient mothers gave birth to neonates suffering from brain injury. 

It means that vitamin D is vital for the protection of the brain in the newborn.  

Vitamin E

Vitamin E is a potent antioxidant. It helps the body get rid of free radicals that can be potentially harmful.

Research in a lab found that vitamin E reduced cellular loss in the brain which means it can aid against the effects of aging on the brain. 

Vitamin B-complex

Vitamin B-complex helps maintain and regulate several vital functions in the body. It consists of water-soluble vitamins ranging from vitamin B1 all the way to B12.

Research in Elsevier indicated that thiamine (vitamin B1) controls the activity of certain enzymes in the brain. In this way, it can help against depression and dementia.  

Vitamin B3 has its implications against environmental toxins. 

Research suggests that vitamin B3 can be a practical choice against neurotoxins. 

A lab trial discovered that vitamin B3 helped recover from traumatic injuries.

So, B3 can effectively play protective roles in the brain.

Like other members of the B-complex family, vitamin B6 also plays an essential role in the brain.

It promotes memory and cognitive functions. 

A clinical trial found that vitamin B6 protected against the damage caused by infectious agents.

Choline Bitartrate

Choline bitartrate contains choline as the primary chemical component. 

Choline is essential for the synthesis of phosphatidylcholine, one of the major neurotransmitters.

Science Direct states in a study that choline can stop the progression of the signs and symptoms of depression. Consequently, there is a possibility of its role in major depressive disorders.

Research on MDPI has also indicated neuroprotective roles of choline as a dietary supplement.

Frontiers in Bioscience concludes in a published study that choline can stop neurodegenerative processes. Thus, there is a strong association of age-related cognitive decline and choline levels in the brain.


Phenylalanine is an essential amino acid. Our body needs a regular supply of this amino acid to function correctly.

Literature shows the role of this ingredient in combating brain pathologies.

However, the evidence is unremarkable.


Inositol resembles vitamins in its chemical structure. It is a part of the metabolic processes at cellular levels.

Study on Research Publishing Group indicates that inositol can play a promising role in Alzheimer's therapy.

Ginkgo Biloba

Ginkgo biloba is an ancient plant. Its extract has been a part of several herbal remedies for ages.

Research on Elsevier showed that ginkgo increases the levels of neurotrophin in the brain. Neurotrophin is a chemical that helps in the learning process.  

However, a look at the medical literature showed that ginkgo could have certain side-effects.

Research at the Department of Dermatology, University of California, hinted that ginkgo could cause contact dermatitis, a skin disease, and Steven-Johnson syndrome. 

Grape Seed Extract 

The grape seed extract is a natural remedy used by many across the globe.

Research in Hindawi Limited hinted towards a possible role of grape seed extract in protection against neurotoxins.

A study also noticed improvement against brain lipotoxicity.         


Glutamine is an amino acid. Its active form, glutamate, is the primary inhibitory neurotransmitter.

The main findings of a trial published on SpringerLink were that l-glutamine is effective against anxiety. 

There is also a possible association with alleviating symptoms of depression.

Trace Elements (like iron, calcium, phosphorus)  

Iron is an essential component of the daily diet. Iron makes the bulk of the volume in red blood cells, so it holds a vital position in the delivery of oxygen to the tissues.

Published research in SpringerLink indicates that iron supplementation can be an effective treatment against Parkinson's disease.

Oxford Academic likes to think of iron as an essential component for healthy growth and development of the brain.

Calcium provides strength to the bones and teeth. 

Research in Wiley indicates that calcium supplementation may be a treatment modality for Alzheimer's disease and brain aging.

However, further research is needed in assessing the role of calcium in promoting brain health.

Phosphorus is a trace element that combines with calcium in the bones to form calcium phosphate. 

A study found that phosphorus can increase glutaminase activity in the brain to protect against the effects of hypoxia on the brain.

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Are EMPowerplus Ingredients Safe & Effective?

We found some concerns regarding the safety profile. A customer reported severe yeast infection after regularly taking the capsules.

Moreover, EMPowerplus Advanced contains ginkgo biloba as one of the main ingredients. 

Medical Literature shows that ginkgo biloba can be a potentially harmful substance. Gingko can cause contact dermatitis, a skin disease, and Steven-Johnson syndrome. 

EMPowerplus Advanced is effective against anxiety, depression, and neurotoxins. 

Studies have also shown an increase in mental power after regular intake of some of the ingredients, especially the vitamins. 

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How to Take EMPowerplus?

Truehope directs that the consumers need to take two capsules daily.                                                      

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Does EMPowerplus Provide 100% BrainPower?

EMPowerplus Advanced is useful against anxiety and depression. It can also protect the brain against toxins. 

But that's about it. 

There is no association of any ingredient with focus, energy levels, or mood.

There is also no evidence of its role against bipolar and ADHD.

So, that's most probably a false claim on the company's side. 

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Warnings for EMPowerplus Users

EMPowerplus Advanced mentions the following warnings on the official website:

  • EMPowerplus Advanced should not be taken alongside any psychotropic or addictive medication without consultation.
  • Pregnant women and people with severe conditions should consult their physicians before use.
  • EMPowerplus Advanced should be kept away from the reach of children.
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Customers Reviews

"I purchased this for my teen daughter, who has struggled with depression, anxiety, and emotional regulation. Within two weeks of taking this, her mood changed. She went from being sullen, defiant, and agitated to much more calm and, dare I say, happy. I can tell when she hasn't been taking it, and almost as soon as she gets back on it, she gets into a much more chilled out mood. She's much more fun to be around, much easier to parent, and just makes life with her so much more fun! Highly recommended."
Jim Nidiffer
"Doesn't work for BIPOLAR 1. Truehope means well, and it's a good multivitamin, but it didn't work for me(2 months)."
Amazon Customer
"I'm sure these are beneficial as a vitamin but by no means provide the results that they claim. As a person with ADD, they do not provide focus at all."
Pam Giesler
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Where to Buy EMPowerplus?

EMPowerplus Advanced can be purchased from Truehope's official store or retailers like Amazon.

The prices are:

  • One bottle for $69.98
  • Two bottles for $139.96

Return Policy & Money-Back Guarantee

Truehope’s return policy states:

  • Any purchased product can be returned within 30 days from the date of purchase.
  • Shipping charges will not be reimbursed.
  • There will be a 25% restocking fee on returns older than 30 days.

Truehope offers 100% money-back guarantee within 30 days from date of purchase. 

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EMPowerplus Alternative - Consumers' No. 1 Choice

EMPowerplus Advanced is a good source of vitamins, including both fat-soluble and water-soluble vitamins. 

These vitamins have scientifically documented effects on the improvement of mental health. 

So, if you use it as a multivitamin, it is a good choice.

However, when it comes to empowering the brain and mental faculties, it does not fulfill the needs of the modern-day brain.

Truehope promotes the product as a solution for ADHD and bipolar on the official website. 

However, their retailer on Amazon mentions a disclaimer that EMPowerplus is not intended to diagnose, treat, cure or prevent any disease.

So, is the long emotional story on the website actually true?

No disrespect, but we can't say anything for sure.

EMPowerplus has not been evaluated by the Food and Drug Administration (FDA). So, the safety profile is still in question.

When it comes to an excellent brain supplement, Mind Lab Pro is a better choice in the market.

Mind Lab Pro contains 11 all-natural ingredients. Each of these ingredients has scientifically documented effects to promote mental health.

Whether it's enhancing focus, or improving the learning curve, Mind Lab Pro is the leader.

Here are some salient features of Mind Lab Pro:

  • Improves cognition
  • Optimum for everyone in the family 
  • Optimizes every brain function 
  • Improves focus
  • Unlocks 100% mental faculties 
  • Boosts mental energy
  • Improves blood flow to the brain
  • Protects against toxins
  • Helps with regeneration after injury
  • Evaluated by third parties for effectiveness
  • Gluten-free
  • Allergen-free
  • Caffeine-Free
  • GMO-free
  • Banned substance-free

EMPowerplus Advanced vs Mind Lab Pro
EMPowerplus Advanced Review – 12 Facts You Need to Know 1
EMPowerplus Advanced Review – 12 Facts You Need to Know 2
Support Memory?Encoding, Storage, Recall, Learning, Test Taking
Support Brain Energy?Mental agility, quick thinking and focus
Supports MindsetMood balance, Stress resistance, Relaxation, Creativity, Motivation
Supports Focus
Supports Brain ProtectionFights toxins and unhealthy structural changes that degrade the brain over time.
Supports PerformanceSpeed, Process, Attention, Focus, Verbal
Supports StructuralInjury repair, Fluid membranes, Neurogenesis, Anti-aging, Fight depression
Meets mental performance demandFrom day to day and hour to hour
Helps with immediate and long-term brain health and function
Free from stimulants and additives
Side Effects
No Potential Side Effects
PricePer Bottle
Free Shipping
Money Back Guarantee
30 Days


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EMPowerplus Advanced is a good source of multi-vitamins. These are great for overall health.

However, when it comes to empowering the brain and mental faculties, it lags in the race.

6.5 Total Score
Not Recommended!

We do not recommend EMPowerplus Advanced. Our recommendation lies with the all-rounder nootropic, Mind Lab Pro.

  • Helps with anxiety and depression
  • Protects against neurotoxins
  • False claims against critical disorders
  • Can lead to skin disorders
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